Southern Comfort (often abbreviated SoCo) is an American liqueur made from neutral spirits with fruit, spice and whiskey flavoring. The brand was originally created by bartender Martin Wilkes Heron in New Orleans in 1874, and is now owned by the Brown-Forman Corporation.

In the US Southern Comfort is available as 100 US proof (50% alcohol by volume), 70 US proof (35% alcohol by volume) and 42 US proof (21% alcohol by volume). Southern Comfort Special Reserve, found in duty-free shops, is a blend of Southern Comfort and bourbon, and is 80 US proof (40% alcohol by volume). Southern Comfort Lime, released in the Summer of 2010, is 55 proof (27.5% alcohol by volume) (UK 2013 20% alcohol by volume) and Southern Comfort Bold Black Cherry, released in the Summer of 2012, is 70 proof (35% alcohol by volume).

Southern Comfort also produces ready-to-pour cocktails available in the US including Southern Comfort Sweet Tea, Southern Comfort Hurricane and Southern Comfort Lemonade, which are all 30 proof (15% alcohol by volume).