Triple sec, originally Curacao triple sec, is a variety of Curacao liqueur, an orange-flavoured liqueur made from the dried peels of bitter and sweet orange.

Triple sec may be consumed neat as a digestif or on the rocks, but is more likely to be used as an ingredient in a variety of cocktails such as the margarita, Kamikaze, White Lady, Long Island Iced Tea, Sidecar, Skittle Bomb, Corpse Reviver #2 and Cosmopolitan.